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Academic Degrees: MD, Medical Faculty Comenius University, Bratislava, 1966 Major Positions and Appointments: 1991-1992 chairman of the Board of Scientists of the Slovak Academy of Sciences 1996-1997 vicechairman of Scientific Grant Agency of the Ministry of Education of the Slovak Republic and Slovak Academy of Sciences (VEGA) 1996-1998 chairman of Scientific Grant Agency of the Ministry of Education of the Slovak Republic and Slovak Academy of Sciences (VEGA) 1993-1999 Member of Committee for Medical and Pharmaceutical sciences VEGA 1993-1999 vicechairman of the Evaluation Committee of the Slovak Academy of Sciences 1993-1996 chairman of the evaluation Committee for medical and pharmaceutical sciences 1990-2003 vicedirector of the Institute of Experimental Endocrinology of the Slovak Academy of Sciences 1996-2002 chairman of the Scientific collegium of the Slovak Academy of Sciences for Medical Sciences 2001- 2003 Member of the Committee of the Agency for support of science and technology
Present appointments 2002- vicechairman of the Scientific collegium of the Slovak Academy of Sciences for Medical sciences 1994- president of the Slovak Physiological Society of the Slovak Medical Society 1997- chairman of the Committee for Doctor of Sciences habilitation in the field of Animal Physiology in the Slovak Republic 1998- member of the Committee for Doctor of Sciences habilitation in the field of Animal Physiology in the Czech Republic 2003- director of the Institute of Experimental Endocrinology of the Slovak Academy of Sciences (Centre of Excellence supported by European Commission)
Editorial boards of scientific journals Cellular and Molecular Neurobiology (USA, NIH) – editor for Europe Physiological Research (Prague): Member of the International Editorial/Advisory Board Iugoslavica Physiologica et Pharmacologica Acta: Member of the International Advisory Board General Physiology and Biophysics (Bratislava) editor Endocrine Regulations (Bratislava) associate editor
Organizer and chairman of the five International symposia on Hormones in Milk, President of the International Symposium on Cell volume and function 1997
One year postdoctoral fellowship in Oregon Health Sciences University in Portland (1977-1978), 1980-1997 INSERM U 297, Faculté de Médecine Nord, Marseille- repeated visits as visiting professor and cooperation resulting in several common publications sponsored by CNRS or INSERM.
Major Research Interests: Developmental neuroendocrinology, hormones in milk, regulation of peptide secretion, cell swelling induced exocytosis Honors, Awards and Prizes: Award of the Slovak Physiological Society for the best publication of the year: 1974, 1981, 1997 Jesenius medal of the Slovak Academy of Sciences for merit in Medical Sciences, 2003 Gold medal of the Slovak Medical Society, 2003 Gold Reiman medal for prevention in medicine.1980 From abroad Laufberger medal of the Czech Physiological Society for merit in Physiology, 2003
Scientists: Július Benický, PhD,
Production and regulation of secretion of protein and peptide hormones, particularly of insulin, thyrotropin releasing hormone and oxytocin in different functional systems. Effect of cell swelling on proteins and peptides secretion and signaling pathway for swelling-induced exocytosis Heart and angiotensin and thyrotropin releasing hormone interaction (TRH)
Thyroxine and TRH are present in maternal milk TRH is present in pancreatic B cells and is important for insulin response to glucose challenge Maturation of the TRH system in rat pancreas could be speeded by glucose challenge during fetal period and slowed by dexamethasone treatment to dams. Cell swelling-induced protein and peptide hormone secretion utilizes unique signaling pathway different from and active in parallel with natural secretagogue. Cell swelling-induced exocytosis is insensitive to physiological inhibition of hormone secretion
In cooperation with
the 2nd Hospital of Pediatrics, School of Medicine, Bratislava, long-term
studies showed the value of breast feeding on the development of the baby
and on its spectrum of lipids and lipoproteins. A too short period of
breast feeding or its absence proved to exert an unfavorable effect. Yet
on the other hand, breast feeding exceeding six months accounted for a
higher cholesterol concentration and atherogenic index at later age. It
was also shown that children of diabetic mothers were more obese and
exhibited higher plasma leptin levels than their age-mates.
I International cooperation with the Institutes in Poland (University of Gdansk), Sweden (University of Uppsala) and France (University of Rouen) included studies on the biological activity of newly synthesized TRH analogs, with the aim to eliminate undesirable and enhance desirable effects. In cooperation with several laboratories in France we further demonstrated that passive immunization aimed at neutralization of endogenous peptides resulted in their increased biosynthesis and secretion.
Slovak Grant Agency
– VEGA 2/3191/23,
2003 – 2005 Traditional and unconventional mechanisms of regulation of
peptide hormone secretion: State Program of the Slovak Republic Cardiogenomics 51/0280800/0280802. Interaction of „hypothalamic“ neuropeptide TRH prudced in the heart with the angiotensin II and gene for renin is being studied .
The methods used in the Laboratory concern in vitro investigations of the secretory activity of isolated pancreatic islets, hypothalamic structures, septum, and neurohypophysis, radioimmunological determination of neurohormones and hormones, as well as pharmacological modulations of secretory processes. The investigations are partly carried out in the human population.
Reviews: Strbak
V. Cell volume and Peptide hormone secretion. Contrib Nephrol.
2006;152:210-220. Strbák V, Greer MA. Regulation of hormone secretion by acute cell volume changes: Ca(2+)-independent hormone secretion. Cell Physiol Biochem. 2000;10:393-402. Editorials: Strbák
V. Neuroscience and Brain Injury. Cell Mol Neurobiol. 2007 Feb 22; [Epub
ahead of print] Strbák V. Heart-the source and target of "hypothalamic neurohormones": do they provide a delicate regulation complementary to the conduction system in the heart? Gen Physiol Biophys. 2000;19:341-343 Most important recent publications: Orečná
M, Hafko R, Bačová Z, Podskočová J, Chorvát Jr D, Strbák V.
Different secretory response of pancreatic islets and insulin secreting
cell lines INS-1 and INS-1E to osmotic stimuli. Physiol Res. 2007 Nov 30;
[Epub ahead of print] Bacová
Z, Orecná M, Hafko R, Strbák V. Cell swelling-induced signaling for
insulin secretion bypasses
steps involving G proteins and PLA2 and is N-ethylmaleimide insensitive. Jakab
M, Grundbichler M, Benicky J, Ravasio A, Chwatal S, Schmidt S, Strbak V, Fürst
J, Paulmichl M, Ritter M. Glucose induces anion conductance and
cytosol-to-membrane transposition of ICln in INS-1E rat insulinoma cells.
Cell Physiol Biochem. 2006;18:21-34. Bacova
Z, Baqi L, Benacka O, Payer J, Krizanová O, Zeman M, Smreková L, Zorad
S, Strbák V. Thyrotropin-releasing hormone in rat heart: effect of
swelling, angiotensin II and renin gene. Acta Physiol (Oxf).
2006;187:313-319. Bacová
Z, Kiss A, Jamal B, Payer J Jr, Strbák V. The effect of swelling on TRH
and oxytocin secretion from hypothalamic structures.Cell Mol Neurobiol.
2006;26:1047-1055. Bacová
Z, Benický J, Lukyanetz EE, Lukyanetz IA, Strbák V. Different signaling
pathways involved in glucose- and cell swelling-induced insulin secretion
by rat pancreatic islets in vitro. Cell Physiol Biochem. 2005;16:59-68. Bacová
Z, Najvirtová M, Krizanová O, Hudecová S, Zórad S, Strbák V, Benický
J. Effect of neonatal streptozotocin and thyrotropin-releasing hormone
treatments on insulin secretion in adult rats. Gen Physiol Biophys.
2005;24:181-197. Kiss
A, Nikodémová M, Kucerová J, Strbák V. Colchicine treatment
differently affects releasable thyrotropin-releasing hormone (TRH) pools
in the hypothalamic paraventricular nucleus (PVN) and the median eminence
(ME). Cell Mol Neurobiol. 2005;25:681-695. Najvirtová
M, Bacová Z, Mátéffyová A, Strbák V. A role of thyrotropin-releasing
hormone in insulin secretion by isolated rat pancreatic islets. Pflugers
Arch. 2005;449:547-552. Kiss
A, Adameová A, Kubovcáková L, Jamal B, Bacová Z, Zórad S, Tybitanclová
K, Kvetnanský R, Strbák V. Effect of immobilization on in vitro
thyrotropin-releasing hormone release from brain septum in wild-type and
corticotropin-releasing hormone knock-out mice. Najvirtová
M, Greer SE, Greer MA, Baqi L, Benický J, Strbák V. Cell volume induced
hormone secretion: studies on signal transduction and specificity. Cell
Physiol Biochem. 2003;13:113-122. Najvirtová
M, Baqi L, Kucerová J, Strbák V. Cell swelling induced secretion of TRH
by posterior pituitary, hypothalamic paraventricular nucleus and
pancreatic islets: effect of L-canavanine. Cell Mol Neurobiol.
2002;22:35-46. Kucerová
J, Strbák V. The osmotic component of ethanol and urea action is critical
for their immediate stimulation of thyrotropin-releasing hormone (TRH)
release from rat brain septum. Kostalova
L, Lesková L, Kapellerová A, Strbák V. Body mass, plasma leptin,
glucose, insulin and C-peptide in offspring of diabetic and non-diabetic
mothers. Eur J Endocrinol. 2001;145:53-58. Strbák
V, Benický J, Nikodémová M. Comparison of pancreatic and
hypophysiotropic TRH systems. Physiol Res. 2000;49:71-78. Benický
J, Nikodémová M, Scsuková S, Zórad S, Strbák V. Four-week ethanol
drinking increases both thyrotropin-releasing hormone (TRH) release and
content in rat pancreatic islets. Life Sci. 2000;66:629-639. Benický
J, Strbák V. Glucose stimulates and insulin inhibits release of
pancreatic TRH in vitro. Eur J Endocrinol. 2000;142:60-65. Nikodémová
M, Greer MA, Strbák V. Hypo-osmolarity stimulates and high sodium
concentration inhibits thyrotropin-releasing hormone secretion from rat
hypothalamus. Nikodémová
M, Benický J, Brtko J, Strbák V. Chronic ethanol drinking and food
deprivation affect rat hypothalamic-pituitary-thyroid axis and TRH in
septum. Endocrine. 1998;9:213-218. Strbák V, Benický J, Macho L, Jezová D, Nikodémová M. Four-week ethanol intake decreases food intake and body weight but does not affect plasma leptin, corticosterone, and insulin levels in pubertal rats. Metabolism. 1998;47:1269-1273.
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